EFFECTS OF PIRACETAM ON N-METHYL-D-ASPARTATE RECEPTOR PROPERTIES IN THE AGED MOUSE-BRAIN

被引：41

作者：

COHEN, SA ^{[1
]}

MULLER, WE ^{[1
]}

机构：

[1] ZENT INST SEEL GESUNDHEIT,PSYCHOPHARMAKOL ABT,D-68159 MANNHEIM,GERMANY

来源：

PHARMACOLOGY | 1993年 / 47卷 / 04期

关键词：

N-METHYL-D-ASPARTATE RECEPTOR; AGING; DEFICIT; PIRACETAM TREATMENT;

D O I：

10.1159/000139100

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Subchronic treatment of aged mice with piracetam (500 mg/kg p.o. for 14 days) elevates N-methyl-D-aspartate (NMDA) receptor density by about 20% and normalizes the enhanced affinity of L-glutamate for the NMDA receptor. Since deficits at the level of the NMDA receptor might be one of the mechanisms underlying age-associated cognitive impairment, the effects reported for piracetam may be relevant for the cognition-enhancing properties of this drug.

引用

页码：217 / 222

页数：6

共 23 条

[21] AGE-RELATED DECREASES OF THE N-METHYL-D-ASPARTATE RECEPTOR COMPLEX IN THE RAT CEREBRAL-CORTEX AND HIPPOCAMPUS
TAMARU, M
YONEDA, Y
OGITA, K
SHIMIZU, J
NAGATA, Y
[J]. BRAIN RESEARCH, 1991, 542 (01) : 83 - 90
[22] PIRACETAM ACTIVITY MAY DIFFER ACCORDING TO THE AGE OF THE RECIPIENT MOUSE
VALZELLI, L
BERNASCONI, S
SALA, A
[J]. INTERNATIONAL PHARMACOPSYCHIATRY, 1980, 15 (03): : 150 - 156
[23] EFFECT OF PIRACETAM ADMINISTRATION ON 3H-N-METHYLSCOPOLAMINE BINDING IN CEREBRAL-CORTEX OF YOUNG AND OLD RATS
VIANA, GSB
MARINHO, MMF
SOUSA, FCF
[J]. LIFE SCIENCES, 1992, 50 (13) : 971 - 977

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