EFFECTS OF PIRACETAM ON N-METHYL-D-ASPARTATE RECEPTOR PROPERTIES IN THE AGED MOUSE-BRAIN

被引：41

作者：

COHEN, SA ^{[1
]}

MULLER, WE ^{[1
]}

机构：

[1] ZENT INST SEEL GESUNDHEIT,PSYCHOPHARMAKOL ABT,D-68159 MANNHEIM,GERMANY

来源：

PHARMACOLOGY | 1993年 / 47卷 / 04期

关键词：

N-METHYL-D-ASPARTATE RECEPTOR; AGING; DEFICIT; PIRACETAM TREATMENT;

D O I：

10.1159/000139100

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Subchronic treatment of aged mice with piracetam (500 mg/kg p.o. for 14 days) elevates N-methyl-D-aspartate (NMDA) receptor density by about 20% and normalizes the enhanced affinity of L-glutamate for the NMDA receptor. Since deficits at the level of the NMDA receptor might be one of the mechanisms underlying age-associated cognitive impairment, the effects reported for piracetam may be relevant for the cognition-enhancing properties of this drug.

引用

页码：217 / 222

页数：6

共 23 条

[11] LOWRY OH, 1951, J BIOL CHEM, V193, P265
[12] D-CYCLOSERINE, A POSITIVE MODULATOR OF THE N-METHYL-D-ASPARTATE RECEPTOR, ENHANCES PERFORMANCE OF LEARNING-TASKS IN RATS
MONAHAN, JB
HANDELMANN, GE
HOOD, WF
CORDI, AA
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 34 (03) : 649 - 653
[13] MORRIS RGM, 1989, J NEUROSCI, V9, P3040
[14] CENTRAL CHOLINERGIC FUNCTIONING AND AGING
MULLER, WE
STOLL, L
SCHUBERT, T
GELBMANN, CM
[J]. ACTA PSYCHIATRICA SCANDINAVICA, 1991, 83 : 34 - 39
[15] MULLER WE, 1990, PSYCHIATRY WORLD PER, V2, P721
[16] PELLEYMOUNTER MA, 1990, PSYCHOBIOLOGY, V18, P298
[17] STRAIN-DEPENDENT DECREASE IN GLUTAMATE BINDING TO THE N-METHYL-D-ASPARTIC ACID RECEPTOR DURING AGING
PETERSON, C
COTMAN, CW
[J]. NEUROSCIENCE LETTERS, 1989, 104 (03) : 309 - 313
[18] PIRACETAM ELEVATES MUSCARINIC CHOLINERGIC RECEPTOR DENSITY IN THE FRONTAL-CORTEX OF AGED BUT NOT OF YOUNG MICE
PILCH, H
MULLER, WE
[J]. PSYCHOPHARMACOLOGY, 1988, 94 (01) : 74 - 78
[19] H-3 LABELED MK-801 BINDING TO THE EXCITATORY AMINO-ACID RECEPTOR COMPLEX FROM RAT-BRAIN IS ENHANCED BY GLYCINE
REYNOLDS, IJ
MURPHY, SN
MILLER, RJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) : 7744 - 7748
[20] REYNOLDS LJ, 1989, MOL PHARMACOL, V33, P581

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