IMMUNOGLOBULIN-V(H)3 GENE-PRODUCTS - NATURAL LIGANDS FOR HIV GP120

被引：255
作者：
BERBERIAN, L
GOODGLICK, L
KIPPS, TJ
BRAUN, J
机构：
[1] UNIV CALIF LOS ANGELES, DEPT PATHOL & LAB MED, LOS ANGELES, CA 90024 USA
[2] UNIV CALIF LOS ANGELES, INST MOLEC BIOL, LOS ANGELES, CA 90024 USA
[3] UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA
来源：
SCIENCE | 1993年 / 261卷 / 5128期
关键词：
D O I：
10.1126/science.7690497
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Infection with human immunodeficiency virus-type 1 (HIV-1) depletes T cells expressing CD4 and B cells expressing immunoglobulin (Ig) V(H)3 gene products. A subpopulation of normal B cells from non-HIV-infected individuals was shown to bind to HIV gp120 by means of membrane Ig; most of these B cells expressed V(H)3 family Ig. Serum V(H)3 IgM from uninfected individuals also avidly bound gp120. Finally, gp120 selectively induced Ig secretion by V(H)3 B cells, indicating that the binding of gp120 functionally activated these cells. These results indicate that naturally occurring V(H)3 Ig is a second ligand for gp120 and a candidate superantigen for V(H)3 B cells.
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页码：1588 / 1591
页数：4
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