Strategies of DNA vaccines against toxoplasmosis

被引：11
作者：
Ghaffarifar, Fatemeh [1 ]
机构：
[1] Tarbiat Modares Univ, Parasitol & Entomol Dept, Fac Med Sci, POB 14115-331, Tehran, Iran
来源：
REVIEWS IN MEDICAL MICROBIOLOGY | 2015年 / 26卷 / 03期
基金：
美国国家科学基金会;
关键词：
adjuvants; DNA vaccine; excreted-secreted antigens; strategies; surface antigens; toxoplasmosis;
D O I：
10.1097/MRM.0000000000000037
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In humans, toxoplasmosis is widespread and can lead to serious disease, especially in pregnant women and also in immunodeficient individuals. The drugs for treatment of this disease have some toxic effects. Hence, the development to either new anti-Toxoplasma drugs or an effective vaccine would be valuable for human medicine. DNA vaccination is one of the most successful strategies for the development of a new generation of effective vaccines against intracellular parasites such as Toxoplasma gondii. This review explains the application of these strategies to improve DNA vaccine efficacy against toxoplasmosis. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
引用
收藏
页码：88 / 90
页数：3
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