Strategies of DNA vaccines against toxoplasmosis

被引：11
作者：
Ghaffarifar, Fatemeh [1 ]
机构：
[1] Tarbiat Modares Univ, Parasitol & Entomol Dept, Fac Med Sci, POB 14115-331, Tehran, Iran
来源：
REVIEWS IN MEDICAL MICROBIOLOGY | 2015年 / 26卷 / 03期
基金：
美国国家科学基金会;
关键词：
adjuvants; DNA vaccine; excreted-secreted antigens; strategies; surface antigens; toxoplasmosis;
D O I：
10.1097/MRM.0000000000000037
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In humans, toxoplasmosis is widespread and can lead to serious disease, especially in pregnant women and also in immunodeficient individuals. The drugs for treatment of this disease have some toxic effects. Hence, the development to either new anti-Toxoplasma drugs or an effective vaccine would be valuable for human medicine. DNA vaccination is one of the most successful strategies for the development of a new generation of effective vaccines against intracellular parasites such as Toxoplasma gondii. This review explains the application of these strategies to improve DNA vaccine efficacy against toxoplasmosis. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
引用
收藏
页码：88 / 90
页数：3
相关论文
共 25 条
[1]   Development of a vaccine for toxoplasmosis: current status [J].
Bhopale, GM .
MICROBES AND INFECTION, 2003, 5 (05) :457-462
[2]   Lytic cycle of Toxoplasma gondii [J].
Black, MW ;
Boothroyd, JC .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000, 64 (03) :607-+
[3]   Synergistic role of micronemal proteins in Toxoplasma gondii virulence [J].
Céréde, O ;
Dubremetz, JF ;
Soête, M ;
Deslée, D ;
Vial, H ;
Bout, D ;
Lebrun, M .
JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (03) :453-463
[4]   Designer vaccines for parasitic diseases [J].
Cox, FEG .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1997, 27 (10) :1147-1157
[5]  
Dubey J. P., 2007, P1, DOI 10.1016/B978-012369542-0/50003-9
[6]  
Eslamirad Z, 2012, AFR J BIOTECHNOL, V11, P10632, DOI DOI 10.5897/AJB10.1860
[7]   Effect of IL-22 on DNA vaccine encoding LACK gene of Leishmania major in BALB/c mice [J].
Hezarjaribi, Hajar Ziaee ;
Ghaffarifar, Fatemeh ;
Dalimi, Abdolhosein ;
Sharifi, Zohreh ;
Jorjani, Ogholniaz .
EXPERIMENTAL PARASITOLOGY, 2013, 134 (03) :341-348
[8]  
Jongert E, 2009, MEM I O CRUZ, V104, P1
[9]   Evaluation of the immune response induced by DNA vaccine cocktail expressing complete SAG1 and ROP2 genes against toxoplasmosis [J].
Khosroshahi, K. Hoseinian ;
Ghaffarifar, F. ;
D'Souza, S. ;
Sharifi, Z. ;
Dalimi, A. .
VACCINE, 2011, 29 (04) :778-783
[10]   Comparing the effect of IL-12 genetic adjuvant and alum non-genetic adjuvant on the efficiency of the cocktail DNA vaccine containing plasmids encoding SAG-1 and ROP-2 of Toxoplasma gondii [J].
Khosroshahi, Kamy Hosseinian ;
Ghaffarifar, Fatemeh ;
Sharifi, Zohre ;
D'Souza, Sushila ;
Dalimi, Abdolhosein ;
Hassan, Zuhair M. ;
Khoshzaban, Fariba .
PARASITOLOGY RESEARCH, 2012, 111 (01) :403-411
123