BIOASSAY OF BOVINE INTERLEUKIN-1-LIKE ACTIVITY

被引：9

作者：

WINSTANLEY, FP ^{[1
]}

ECKERSALL, PD ^{[1
]}

机构：

[1] UNIV GLASGOW, SCH VET, DEPT VET BIOCHEM, GLASGOW G61 1QH, SCOTLAND

来源：

RESEARCH IN VETERINARY SCIENCE | 1992年 / 52卷 / 03期

关键词：

D O I：

10.1016/0034-5288(92)90024-V

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A bioassay for bovine interleukin-1 (IL1) activity is described. The assay is based on the IL1-stimulated proliferation of a mouse T-lymphocyte cell line, D10(N4)M. Bovine mononuclear cells stimulated with lipopolysaccharide produce an interleukin-1-like activity which stimulated the growth of the D10(N4)M cell line in a dose-dependent manner. The stimulatory activity was neutralised by a combination of both anti-human IL1-alpha and anti-human IL1-beta sera. The quantity of IL1-like activity released from the mononuclear cells increased asymptotically with increasing lipopolysaccharide dose.

引用

页码：273 / 276

页数：4

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