SEGMENTAL ORGANIZATION OF EMBRYONIC DIENCEPHALON

被引：363
作者：
FIGDOR, MC
STERN, CD
机构：
[1] UNIV OXFORD,DEPT HUMAN ANAT,S PARKS RD,OXFORD OX1 3QX,ENGLAND
[2] INST HISTOL & EMBRYOL,A-1090 VIENNA,AUSTRIA
来源：
NATURE | 1993年 / 363卷 / 6430期
基金：
英国惠康基金;
关键词：
D O I：
10.1038/363630a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
THE diencephalon is a complex integration centre and intricate relay station of the vertebrate brain1-3. Its development involves the generation of great cellular diversity and neuronal specificity. We report here that it becomes organized in steps, through a stereotyped sequence of neuromeric subdivisions. Diencephalic neuromeres define four cellular domains (D1-D4) that can be followed throughout development, each unit contributing to a well defined part of the adult structural pattern. We propose that the segmental identity of each diencephalic unit is specified by a unique combination of genes4-13, maintained by polyclonal cell lineage restrictions. A comparison of vertebrate and arthropod development suggests that the basic principles that control anterior axial patterning and set up neuronal specificity in the embryonic central nervous system are highly conserved in evolution.
引用
收藏
页码：630 / 634
页数：5
相关论文
共 37 条
[11]  
KEYSER AJM, 1972, ACTA ANAT S59, V83, P1
[12]   EXPRESSION PATTERN OF ZEBRAFISH PAX GENES SUGGESTS A ROLE IN EARLY BRAIN REGIONALIZATION [J].
KRAUSS, S ;
JOHANSEN, T ;
KORZH, V ;
FJOSE, A .
NATURE, 1991, 353 (6341) :267-270
[13]  
Kuhlenbeck H., 1973, CENTRAL NERVOUS SYST
[14]   DEVELOPMENTAL BIOLOGY - COMPARTMENTS IN VERTEBRATES [J].
LAWRENCE, PA .
NATURE, 1990, 344 (6265) :382-383
[15]  
LAYER PG, 1990, DEVELOPMENT, V109, P613
[16]   SEGMENTAL PATTERNS OF NEURONAL DEVELOPMENT IN THE CHICK HINDBRAIN [J].
LUMSDEN, A ;
KEYNES, R .
NATURE, 1989, 337 (6206) :424-428
[17]   INDUCTION OF A MESENCEPHALIC PHENOTYPE IN THE 2-DAY-OLD CHICK PROSENCEPHALON IS PRECEDED BY THE EARLY EXPRESSION OF THE HOMEOBOX GENE EN [J].
MARTINEZ, S ;
WASSEF, M ;
ALVARADOMALLART, RM .
NEURON, 1991, 6 (06) :971-981
[18]   HOMEOBOX GENES AND AXIAL PATTERNING [J].
MCGINNIS, W ;
KRUMLAUF, R .
CELL, 1992, 68 (02) :283-302
[19]  
MCGREW LL, 1992, DEVELOPMENT, V115, P463
[20]   ISOLATION AND CHARACTERIZATION OF A NOVEL CDNA CLONE ENCODING A HOMEODOMAIN THAT IS DEVELOPMENTALLY REGULATED IN THE VENTRAL FOREBRAIN [J].
PORTEUS, MH ;
BULFONE, A ;
CIARANELLO, RD ;
RUBENSTEIN, JLR .
NEURON, 1991, 7 (02) :221-229
1234