DESIGN OF SPECIFIC IMMUNOGENS USING FILAMENTOUS PHAGE AS THE CARRIER

Earlier, we developed an expression vector allowing exposure of short peptides on the surface of bacteriophage M 1 3. It was used to obtain a recombinant phage carrying an antigenic determinant of HIV 1 p 17 Gag protein. Immunoglobulin elicited by immunizing rabbits with the phage reacted with the 17-kDa core protein of the virus and with its polyprotein precursor, p55, on Western blots of HIV1 viral proteins. The results of present experiments may be useful in vaccine development.