ALLERGIC CONTACT REACTION TO DEXPANTHENOL - LYMPHOCYTE-TRANSFORMATION TEST AND EVIDENCE FOR MICROSOMAL-DEPENDENT METABOLISM OF THE ALLERGEN

In a patient with contact dermatitis, dexpanthenol was found to be the causative allergen. There was a positive reaction to dexpanthenol on patch testing. Controls did not show any positive reactions to dexpanthenol on patch testing. Additionally, an LTT was performed. After preincubation with dexpanthenol-modified microsomes, we observed an increase in lymphocyte proliferation to dexpanthenol, in comparison to dexpanthenol without microsomes, suggesting that microsomal metabolism plays a role in the pathogenesis of dexpanthenol sensitization, because microsomes are known to posses drug metabolizing enzymes such as cytochrome P450.