ANALYSIS OF EGG GRANULOMA-FORMATION IN SCHISTOSOMA-JAPONICUM-INFECTED MICE TREATED WITH ANTIBODIES TO INTERLEUKIN-5 AND GAMMA-INTERFERON

被引:34
作者
CHEEVER, AW
XU, YH
SHER, A
MACEDONIA, JG
机构
关键词
D O I
10.1128/IAI.59.11.4071-4074.1991
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Schistosoma japonicum-infected mice were treated with antibodies to interleukin-5 (IL-5) or gamma interferon (IFN-gamma) from week 3 or 4 to week 10 of infection. Neither antibody affected egg production by the parasite, and neither had a consistent effect on the secretion of IFN-gamma or IL-5 cell-related cytokines by spleen cells from infected mice. Mice treated with antibody to murine IL-5 had only rare eosinophils in hepatic circumoval granulomas. Granulomas around single eggs were reduced in volume by a third, but hepatic fibrosis was unaffected. Treatment with antibody to murine IFN-gamma also reduced the size of granulomas and also did not affect hepatic fibrosis, which was measured as hydroxyproline. Our results, taken together with the studies of others, indicate that a complex interaction of cytokines affects granuloma size and that the size and fibrosis of granulomas are to some extent regulated independently.
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页码:4071 / 4074
页数:4
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