ZOTEPINE IN THE TREATMENT OF SCHIZOPHRENIC-PATIENTS WITH PREVAILINGLY NEGATIVE SYMPTOMS - A DOUBLE-BLIND TRIAL VS HALOPERIDOL

被引：80
作者：
BARNAS, C
STUPPACK, CH
MILLER, C
HARING, C
SPERNERUNTERWEGER, B
FLEISCHHACKER, WW
机构：
[1] Biological Psychiatry Research Unit, Department of Psychiatry, University of Innsbruck
来源：
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 1992年 / 7卷 / 01期
关键词：
D O I：
10.1097/00004850-199200710-00003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Zotepine, a neuroleptic agent with additional 5-HT2 blocking properties, was compared with haloperidol in the treatment of schizophrenic patients with predominantly negative symptoms using a double-blind design. During the investigation period zotepine treated patients showed significant improvements in all rating instruments whereas haloperidol treated patients did not. Patients in the zotepine group developed fewer clinical side effects. The results of the presented study confirm the positive impressions gained in earlier open trials with zotepine.
引用
收藏
页码：23 / 27
页数：5
相关论文
共 30 条
  • [1] AMAMOTO H, 1980, CLIN REPORT, V14, P292
  • [2] DIFFERENTIAL-EFFECTS OF AMPHETAMINE AND NEUROLEPTICS ON NEGATIVE VS POSITIVE SYMPTOMS IN SCHIZOPHRENIA
    ANGRIST, B
    ROTROSEN, J
    GERSHON, S
    [J]. PSYCHOPHARMACOLOGY, 1980, 72 (01) : 17 - 19
  • [3] ARIKAWA K, 1980, JPN J CLIN PSYCHIATR, V9, P101
  • [4] TREATMENT OF NEGATIVE SYMPTOMS IN SCHIZOPHRENIA WITH ZOTEPINE
    BARNAS, C
    STUPPAECK, C
    UNTERWEGER, B
    HINTERHUBER, H
    FLEISCHHACKER, WW
    [J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 1987, 7 (05) : 370 - 371
  • [5] DIFFERENTIAL RESPONSE TO AMPHETAMINE IN SCHIZOPHRENIA
    CESAREC, Z
    NYMAN, AK
    [J]. ACTA PSYCHIATRICA SCANDINAVICA, 1985, 71 (05) : 523 - 538
  • [6] EFFECT OF SEROTONIN ANTAGONISM IN SCHIZOPHRENIA - A PILOT-STUDY WITH SETOPERONE
    CEULEMANS, DLS
    GELDERS, YG
    HOPPENBROUWERS, MLJA
    REYNTJENS, AJM
    JANSSEN, PAJ
    [J]. PSYCHOPHARMACOLOGY, 1985, 85 (03) : 329 - 332
  • [7] CSERNANSKY JG, 1986, HOSP FORMUL, V21, P790
  • [8] PRELIMINARY EXPERIENCES AND RESULTS WITH THE MUNICH VERSION OF THE ANDREASEN SCALE - ASSESSMENT OF PRODUCTIVE AND NEGATIVE SYMPTOMS IN CHRONIC-SCHIZOPHRENIC PATIENTS
    DIETERLE, DM
    ALBUS, MI
    EBEN, E
    ACKENHEIL, M
    ROCKSTROH, W
    [J]. PHARMACOPSYCHIATRY, 1986, 19 (03) : 96 - 100
  • [9] DIETERLE DM, 1991, FORTSCHR NEUROL PSYC, V1, P18
  • [10] ZOTEPINE IN THE TREATMENT OF NEGATIVE SYMPTOMS IN CHRONIC-SCHIZOPHRENIA
    FLEISCHHACKER, WW
    BARNAS, C
    STUPPACK, C
    UNTERWEGER, B
    HINTERHUBER, H
    [J]. PHARMACOPSYCHIATRY, 1987, 20 : 58 - 60
123