ENZYME ASSISTED PREPARATION OF ENANTIOMERICALLY PURE BETA-ADRENERGIC BLOCKERS .1. A FACILE SCREENING METHOD FOR SUITABLE BIOCATALYSTS

被引：28

作者：

ADER, U ^{[1
]}

SCHNEIDER, MP ^{[1
]}

机构：

[1] UNIV GESAMTHSCH WUPPERTAL, FACHBEREICH BERG 9, W-5600 WUPPERTAL 1, GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(00)80190-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselective preparation of potential precursors for beta-adrenergic blockers was studied by enzymatic hydrolysis of the corresponding ester derivatives. Based on the facile separation of both substrates and products by HPLC on a chiral support a convenient screening method was developed for a rapid evaluation of the best suited esterhydrolase.

引用

页码：201 / 204

页数：4

共 29 条

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