EXPRESSION OF ACTIN AND MYOSIN GENES DURING PC12 CELL-DIFFERENTIATION

被引：13
|
作者：
HENKE, RC
TOLHURST, O
SENTRY, JW
GUNNING, P
JEFFREY, PL
机构：
[1] CHILDRENS MED RES FDN,DEPT MUSCLE GENET,POB 61,CAMPERDOWN,NSW 2050,AUSTRALIA
[2] CHILDRENS MED RES FDN,DEPT DEV NEUROBIOL,CAMPERDOWN,NSW 2050,AUSTRALIA
来源：
NEUROCHEMICAL RESEARCH | 1991年 / 16卷 / 06期
关键词：
PC12; DIFFERENTIATION; NGF; BETA-ACTIN AND GAMMA-ACTIN; MLC2; AND; 3NM;
D O I：
10.1007/BF00965554
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have measured the accumulation of transcripts for myosin and actin during NGF induced differentiation of PC12 cells. Beta (beta) and gamma (gamma) actin and myosin light chains (MLC) 2 and 3 show different patterns of expression, with transient elevations in gene expression one day after NGF addition. This elevation occurs earlier than that of neurite outgrowth, neurofilament protein (NF68) (16) and Thy-1 glycoprotein gene expression. These results suggest differing mechanisms of control of actin and myosin expression, together with a varying function and relationship between them during NGF - induced neurite differentiation.
引用
收藏
页码：675 / 679
页数：5
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