AN ION-STORAGE TIME-OF-FLIGHT MASS-SPECTROMETER FOR ANALYSIS OF ELECTROSPRAY IONS

被引：32

作者：

BOYLE, JG ^{[1
]}

WHITEHOUSE, CM ^{[1
]}

FENN, JB ^{[1
]}

机构：

[1] YALE UNIV,DEPT CHEM ENGN,NEW HAVEN,CT 06520

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1991年 / 5卷 / 09期

关键词：

D O I：

10.1002/rcm.1290050906

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A preliminary design and implementation of a novel approach to electrospray-mass spectrometry are described. Based on a time-of-flight mass analysis, the instrument provides several important advantages for on-line mass analysis: 1, simplicity, ease of use and low manufacturing cost; 2, rapid scan speed, yielding quasi-instantaneous full mass scans at repetition rates up to several kHz; 3, soft ionization and accurate mass determination of extremely large analyte molecules; 4, high sensitivity.

引用

页码：400 / 405

页数：6

共 19 条

[1] BEAM-MODULATED TIME-OF-FLIGHT MASS-SPECTROMETER .2. EXPERIMENTAL WORK [J].

BAKKER, JMB .

JOURNAL OF PHYSICS E-SCIENTIFIC INSTRUMENTS, 1974, 7 (05) :364-368

[2] BEAM-MODULATED TIME-OF-FLIGHT MASS-SPECTROMETER .1. THEORETICAL CONSIDERATIONS [J].

BAKKER, JMB .

JOURNAL OF PHYSICS E-SCIENTIFIC INSTRUMENTS, 1973, 6 (08) :785-789

[3]

Chen K H, 1988, Rapid Commun Mass Spectrom, V2, P237, DOI 10.1002/rcm.1290021107

[4] ELECTROSPRAY IONIZATION FOR MASS-SPECTROMETRY OF LARGE BIOMOLECULES [J].

FENN, JB ;

MANN, M ;

MENG, CK ;

WONG, SF ;

WHITEHOUSE, CM .

SCIENCE, 1989, 246 (4926) :64-71

[5] SECONDARY-ELECTRON EMISSION INDUCED BY IMPACT OF LOW-VELOCITY MOLECULAR-IONS ON A MICROCHANNEL PLATE [J].

GENO, PW ;

MACFARLANE, RD .

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1989, 92 :195-210

[6] AN ELECTRON-IMPACT STORAGE ION-SOURCE FOR TIME-OF-FLIGHT MASS SPECTROMETERS [J].

GRIX, R ;

GRUNER, U ;

LI, G ;

STROH, H ;

WOLLNIK, H .

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1989, 93 (03) :323-330

[7] MASS-SPECTROMETRY ON THE CHROMATOGRAPHIC TIME SCALE - REALISTIC EXPECTATIONS [J].

HOLLAND, JF ;

ENKE, CG ;

ALLISON, J ;

STULTS, JT ;

PINKSTON, JD ;

NEWCOME, B ;

WATSON, JT .

ANALYTICAL CHEMISTRY, 1983, 55 (09) :A997-&

[8] ATMOSPHERIC-PRESSURE IONIZATION MASS-SPECTROMETRY - DETECTION FOR THE SEPARATION SCIENCES [J].

HUANG, EC ;

WACHS, T ;

CONBOY, JJ ;

HENION, JD .

ANALYTICAL CHEMISTRY, 1990, 62 (13) :A713-+

[9]

NOHMI JB, 1990, SCIENCE

[10]

NOHMI T, 1990, 38TH P ASMS C MASS S, P10

← 1 2 →