BLISTER FLUID PROTEINASES IN BULLOUS SKIN DISEASES

被引：3

作者：

FRAKI, JE

机构：

[1] Department of Dermatology, University of Turku, Turku

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 1979年 / 4卷 / 04期

关键词：

D O I：

10.1111/j.1365-2230.1979.tb01643.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Blister fluids from various vesiculo‐bullous skin diseases were found to hydrolyse several proteinase substrates at almost the same pH optima as healthy human skin extracts. Hydrolysis rates of substrates by different blister samples were found to vary greatly. High hydrolysis rates were found in dermatitis herpetiformis (hydrolysis of casein at pH 75) and in acute infected eczema (hydrolysis of haemoglobin at pH 3.5 and casein at pH 7.5), whilst slow hydrolysis rates were found in burn blisters. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：471 / 475

页数：5

共 20 条

[1]

Bauer E.A., Gedde-Dahl T., Jr, Eisen A.Z., The role of human skin collagenase in epidermolysis bullosa, Journal of Investigative Dermatology, 68, pp. 119-124, (1977)

[2]

Beloff A., Peters R.A., Observations upon thermal burns: the influence of moderate temperature burns upon a proteinase of skin, The Journal of Physiology, 103, pp. 461-476, (1945)

[3]

Beloff A., Peters R.A., An investigation for the presence of a skin protease inhibitory factor in burned skin, Journal of Physiology, 105, pp. 54-57, (1946)

[4]

Braun-Falco O., Salfield K., Über das Verhalten der Leucin‐Aminopeptidase‐Aktivität im Blutserum und Blaseninhalt. I. Mitteilung. Untersuchung an Hautgesunden, Archiv für klinische und experimentelle Dermatologie, 204, pp. 407-415, (1957)

[5]

Dougherty J.W., Cormia F.E., Unrau S., Proteolytic activity in pemphigus. II. Estimation in skin and blood, Archives of Dermatology, 77, pp. 281-284, (1958)

[6]

Einbinder J.M., Walzer R.A., Mandl I., Epidermal‐dermal separation with proicolytic enzymes, J Invest Dermatol, 46, pp. 492-504, (1966)

[7]

Eisen A.Z., Human skin collagenase: relationship to the pathogenesis of epidermolysis bullosa dystrophica, Journal of Investigative Dermatology, 52, pp. 449-453, (1969)

[8]

Fraki J.E., Hopsu-Havu V.K., Human skin proteases. Differential extraction of proteases and of endogenous inhibitors, Archiv für Dermatologische Forschung, 243, pp. 329-342, (1972)

[9]

Fraki J.E., Hopsu-Havu V.K., Human skin proteases. Partial purification and characterization of a protease inhibitor, Archiv für Dermatologische Forschung, 243, pp. 153-163, (1972)

[10]

Fraki J.E., Hopsu-Havu V.K., Human skin protease. Separation and characterization of two alkaline proteases, one splitting trypsin and the other chymotrypsin substrates, Archives of Dermatological Research, 253, pp. 261-276, (1975)

← 1 2 →