CHOLECYSTOKININ OCTAPEPTIDE - CONTINUOUS PICOMOLE INJECTIONS INTO THE CEREBRAL-VENTRICLES OF SHEEP SUPPRESS FEEDING

被引：360

作者：

DELLAFERA, MA

BAILE, CA

机构：

[1] School of Veterinary Medicine, University of Pennsylvania, Kennett Square

来源：

SCIENCE | 1979年 / 206卷 / 4417期

关键词：

D O I：

10.1126/science.504989

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cholecystokinin octapeptide decreased food intake in a dose-related manner when injected continuously into the lateral cerebral ventricles of sheep that had been deprived of food for 2, 4, 8, or 24 hours. In sheep deprived of food for 2 hours, as little as 0.01 picomole per minute suppressed feeding 35 percent 1 hour after beginning injection. Pentagastrin also decreased feeding in the 2-hour group, but only at a much higher dose range. Secretin had no effect. These findings support the hypothesis that cholecystokinin octapeptide acts on central nervous system structures that are involved in control of food intake. Copyright © 1979 AAAS.

引用

页码：471 / 473

页数：3

共 16 条

[1]

BAILE CA, 1975, DIGESTION METABOLISM, P333

[2] ISOLATION, STRUCTURE AND BIOLOGICAL-ACTIVITY OF 2 CHOLECYSTOKININ OCTAPEPTIDES FROM SHEEP BRAIN [J].