CHONDROCYTE MEDIATED CARTILAGE DEGRADATION - REGULATION BY PROSTAGLANDIN-E2, CYCLIC-AMP AND INTERFERON-ALPHA

被引：0
|
作者：
STEINBERG, JJ [1 ]
SLEDGE, CB [1 ]
机构：
[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT ORTHOPED SURG,ORTHOPED RES LAB,BOSTON,MA 02115
来源：
JOURNAL OF RHEUMATOLOGY | 1991年 / 18卷
关键词：
CARTILAGE; ENDOTOXIN; TNF; INTERFERONS; CAMP; PGE(2);
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Local responses to cytokines and their induced products play a critical role in outcome in the arthritic joint. Using a bovine nasal cartilage culture model, chondrocyte mediated breakdown was stimulated by lipopolysaccharides or tumor necrosis factor. Cartilage breakdown was inhibited in a dose dependent manner by prostaglandin E2, cyclic AMP enhancement and interferon alpha. The possible regulatory roles played by these agents in cytokine activated cartilage breakdown suggest potential therapeutic strategies in human arthritis.
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页码：63 / 65
页数：3
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