LOW BASAL AND STIMULATED RELEASE OF NITRIC-OXIDE IN ATHEROSCLEROTIC EPICARDIAL CORONARY-ARTERIES

被引：255

作者：

CHESTER, AH

ONEIL, GS

MONCADA, S

TADJKARIMI, S

YACOUB, MH

机构：

[1] HAREFIELD HOSP,NATL HEART & LUNG INST,THORAC & CARDIAC SURG UNIT,HAREFIELD UB9 6JH,MIDDX,ENGLAND

[2] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

LANCET | 1990年 / 336卷 / 8720期

关键词：

D O I：

10.1016/0140-6736(90)92269-N

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelium-dependent relaxations in response to substance P and bradykinin were lower in atherosclerotic than in normal human coronary arteries. The relaxation induced by substance P was inhibited by L-NG-monomethylarginine (L-NMMA), which shows that release of nitric oxide is involved in the mediation of endothelium-dependent relaxation in these arteries. L-NMMA also inhibited a basal component of endothelium-dependent relaxation. The basal secretion of nitric oxide was significantly lower in diseased than in normal arteries. These findings suggest that atherosclerotic human coronary arteries lack an important protective mechanism that normally guards against vasospasm and thrombosis. © 1990.

引用

页码：897 / 900

页数：4

共 20 条

[1] NG-METHYLARGININE, AN INHIBITOR OF ENDOTHELIUM-DERIVED NITRIC-OXIDE SYNTHESIS, IS A POTENT PRESSOR AGENT IN THE GUINEA-PIG - DOES NITRIC-OXIDE REGULATE BLOOD-PRESSURE INVIVO [J].