HYPOXIC PULMONARY VASOCONSTRICTION AND REGIONAL AND WHOLE-LUNG PEEP IN THE DOG

被引:43
作者
BENUMOF, JL [1 ]
ROGERS, SN [1 ]
MOYCE, PR [1 ]
BERRYHILL, RE [1 ]
WAHRENBROCK, EA [1 ]
SAIDMAN, LJ [1 ]
机构
[1] UNIV CALIF SAN DIEGO,DEPT ANESTHESIA,LA JOLLA,CA 92093
关键词
D O I
10.1097/00000542-197912000-00004
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
In open-chested (Group I) and closed-chested (Group II) dogs, the authors examined the effects of the application of regional and whole-lung PEEP (10 torr) on the partitioning of electromagnetically measured blood flow between a normoxic and a hypoxic compartment of the lung. In both Group I and Group II when the left lower lobe (LLL) was made the hypoxic compartment 1, by ventilation with nitrogen, 95 per cent, CO 2, 5 per cent, and 2, by causing complete absorption atelectasis, LLL blood flow-to-total pulmonary blood flow ratio (Q(LLL)/Q(t) decreased 32-56 per cent. PEEP to the normoxic compartment (rest of the lung) during LLL hypoxia increased Q(LLL)/Q(t) significantly in both Group I (from 12 ± 2 to 35 ± 7 per cent) and Group II (from 8 ± 1 to 11 ± 1 per cent), but the increase was much greater in Group I, and transmural pulmonary arterial pressure increased significantly (6 ± 1 torr) in Group I only. PEEP to both the hypoxic LLL and the normoxic rest of the lung increased Q(LLL)/Q(t) significantly in Group I only (from 12 ± 2 to 19 ± 4 per cent) and transmural pulmonary arterial pressure increased significantly (7 ± 1 torr) in Group I only. PEEP to just the hypoxic LLL decreased Q(LLL)/Q(t) significantly in both Group I (from 12 ± 2 to 7 ± 1 per cent) and Group II (from 8 ± 1 to 5 ± 0.4 per cent). It is concluded that, in addition to the usual increase in regional functional residual capacity, the effect of PEEP on diseased lung is a summation of its beneficial and deleterious regional effects on the partitioning of blood flow between hypoxic and normoxic compartments of the lung.
引用
收藏
页码:503 / 507
页数:5
相关论文
共 10 条
[1]   BLUNTED HYPOXIC PULMONARY VASOCONSTRICTION BY INCREASED LUNG VASCULAR PRESSURES [J].
BENUMOF, JL ;
WAHRENBROCK, EA .
JOURNAL OF APPLIED PHYSIOLOGY, 1975, 38 (05) :846-850
[2]   LOCAL EFFECTS OF ANESTHETICS ON REGIONAL HYPOXIC PULMONARY VASOCONSTRICTION [J].
BENUMOF, JL ;
WAHRENBROCK, EA .
ANESTHESIOLOGY, 1975, 43 (05) :525-532
[3]   CYCLIC HYPOXIC PULMONARY VASOCONSTRICTION INDUCED BY CONCOMITANT CARBON-DIOXIDE CHANGES [J].
BENUMOF, JL ;
MATHERS, JM ;
WAHRENBROCK, EA .
JOURNAL OF APPLIED PHYSIOLOGY, 1976, 41 (04) :466-469
[4]   INFLUENCE OF PULMONARY ARTERIAL AND LEFT ATRIAL PRESSURES ON PULMONARY VASCULAR RESISTANCE [J].
BORST, HG ;
MCGREGOR, M ;
WHITTENBERGER, JL ;
BERGLUND, E .
CIRCULATION RESEARCH, 1956, 4 (04) :393-399
[5]  
CHERNIACK RM, 1972, RESPIRATION HLTH DIS, P305
[6]   PHYSIOLOGIC CONSEQUENCES OF POSITIVE END-EXPIRATORY PRESSURE (PEEP) VENTILATION [J].
POWERS, SR ;
MANNAL, R ;
NECLERIO, M ;
ENGLISH, M ;
MARR, C ;
LEATHER, R ;
UEDA, H ;
WILLIAMS, G ;
CUSTEAD, W ;
DUTTON, R .
ANNALS OF SURGERY, 1973, 178 (03) :265-272
[7]   INFLUENCE OF INFLATION AND ATELECTASIS ON HYPOXIC PRESSOR-RESPONSE IN ISOLATED DOG LUNG LOBES [J].
QUEBBEMAN, EJ ;
DAWSON, CA .
CARDIOVASCULAR RESEARCH, 1976, 10 (06) :672-677
[8]   PULMONARY VASCULAR RESISTANCE AS DETERMINED BY LUNG INFLATION AND VASCULAR PRESSURES [J].
ROOS, A ;
THOMAS, LJ ;
NAGEL, EL ;
PROMMAS, DC .
JOURNAL OF APPLIED PHYSIOLOGY, 1961, 16 (01) :77-&
[9]   PHYSICAL FACTORS AFFECTING NORMAL AND SEROTONIN-CONSTRICTED PULMONARY VESSELS [J].
RUDOLPH, AM ;
AULD, PAM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1960, 198 (04) :864-872
[10]   OPTIMUM END-EXPIRATORY AIRWAY PRESSURE IN PATIENTS WITH ACUTE PULMONARY FAILURE [J].
SUTER, PM ;
FAIRLEY, HB ;
ISENBERG, MD .
NEW ENGLAND JOURNAL OF MEDICINE, 1975, 292 (06) :284-289