LIN-BENZOADENINE NUCLEOTIDES - INTER-MOLECULAR AND INTRA-MOLECULAR INTERACTIONS IN AQUEOUS-SOLUTIONS AS OBSERVED BY PROTON MAGNETIC-RESONANCE

被引：19

作者：

BARRIO, JR ^{[1
]}

LIU, FT ^{[1
]}

KEYSER, GE ^{[1
]}

VANDERLIJN, P ^{[1
]}

LEONARD, NJ ^{[1
]}

机构：

[1] UNIV ILLINOIS,ROGER ADAMS LAB,SCH CHEM SCI,URBANA,IL 61801

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1979年 / 101卷 / 06期

关键词：

D O I：

10.1021/ja00500a032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The inter-and intramolecular interactions of lin-benzoadenine nucleotides have been examined by proton magnetic resonance. When the base is unprotonated, lin-benzoadenine nucleotides strongly stack m aqueous solution?with association constants of at least one order of magnitude greater than those of the corresponding adenine nucleotides. Some head-to-tail orientations of stacked lin-benzoadenine nucleotides were indicated by the deuterium substitution effect on relaxation times (DESERT). The relative positions of the heteroar?matic proton chemical shifts at infinite dilution (pD 8.5) and under aciaic conditions (pD ~4.0) indicated the conformations of the nucleotides (anti and syn, respectively) and the site of ring protonation (the pyrimidine ring). © 1979, American Chemical Society. All rights reserved.

引用

页码：1564 / 1569

页数：6

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