EFFECTS OF PERIFORNICAL HYPOTHALAMIC MICROINJECTIONS OF PHENYLPROPANOLAMINE AND AMPHETAMINE ON LATENCY TO FEED AND MASH INTAKE IN RATS

被引：23
|
作者：
WELLMAN, PJ
COCKROFT, R
机构：
[1] Department of Psychology, Texas A and M University, College Station
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 35卷 / 02期
关键词：
Amphetamine; Anorexia; Food intake; Perifornical hypothalamus; Phenylpropanolamine;
D O I：
10.1016/0091-3057(90)90185-K
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
To determine whether phenylpropanolamine (PPA) and amphetamine act on a common satiety mechanism, the present experiment compared the effect of unilateral microinjections (40, 80, and 160 nmol) of phenylpropanolamine hydrochloride (PPA: d,l-norephedrine) and of d-amphetamine sulfate within the perifornical hypothalamus (PFH) on consumption of a palatable sweetened-mash diet in adult male rats. Microinjection of d-amphetamine (40-160 nmol) within the PFH induced dose-dependent anorexia, whereas PPA microinjections were without effect on feeding. These results document that amphetamine and PPA do not act at a common CNS site, such as the PFH, to induce anorexia. © 1990.
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页码：461 / 464
页数：4
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