ERYTHROPOIETIN DEFICIENCY IN ACUTE TUBULAR-NECROSIS

被引：39

作者：

NIELSEN, OJ ^{[1
]}

THAYSEN, JH ^{[1
]}

机构：

[1] RIGSHOSP,DEPT MED P,DK-2100 COPENHAGEN,DENMARK

来源：

JOURNAL OF INTERNAL MEDICINE | 1990年 / 227卷 / 06期

关键词：

acute renal failure; acute tubular necrosis; anaemia; erythropoietin;

D O I：

10.1111/j.1365-2796.1990.tb00175.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abstract. Serum erythropoietin (EPO) concentrations were markedly depressed relative to the degree of anaemia in 10 patients with acute tubular necrosis, and remained low long after restoration of excretory renal function as estimated by glomerular filtration rate. Evidence is presented that the low serum EPO level is due to defective synthesis and not to increased catabolism. It is suggested that the predominantly aregeneratory anaemia found in prolonged cases of acute tubular necrosis, and the slow restoration of red cell mass during recovery, are due to the deficient synthesis of EPO. A positive erythropoietic response in a therapeutic trial with recombinant human erythropoietin (rhEPO) appears to support this hypothesis. 1990 Blackwell Publishing Ltd

引用

页码：373 / 380

页数：8

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