Acute Respiratory Distress Syndrome and Posterior Reversible Encephalopathy Syndrome following Rituximab Therapy

被引：3
|
作者：
Wardrope, Katrina E. [1 ]
Manson, Lynn [2 ]
Metcalfe, Wendy [1 ]
Sullivan, Eoin D. O. [1 ]
机构：
[1] Royal Infirm Edinburgh NHS Trust, Dept Renal Med, 51 Little France Crescent, Edinburgh EH16 5SY, Midlothian, Scotland
[2] Scottish Natl Blood Transfus Serv, Edinburgh, Midlothian, Scotland
来源：
CASE REPORTS IN NEPHROLOGY AND DIALYSIS | 2016年 / 6卷 / 01期
关键词：
Rituximab; Acute respiratory distress syndrome; Posterior reversible encephalopathy syndrome; Cryoglobulinaemia;
D O I：
10.1159/000444250
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The anti-CD20 monoclonal antibody rituximab is associated with rare but significant adverse events, notably posterior reversible encephalopathy syndrome (PRES) and acute respiratory distress syndrome (ARDS). We report a case of concomitant ARDS and PRES developing after rituximab therapy for treatment of cryoglobulinaemic vasculitis. There are 7 reported cases of PRES complicating rituximab use. PRES onset varied from immediate to 21 days after administration. All patients recovered completely, and rituximab was reintroduced in half of the cases. The occurrence of ARDS in association with rituximab is rarer. Only 3 confirmed cases exist, and ARDS may occur as a delayed reaction. (C) 2016 The Author(s) Published by S. Karger AG, Basel
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页码：32 / 39
页数：8
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