NITROHETEROCYCLIC ANTIMICROBIAL AGENTS .I. NITROTHIAZOLECARBOXALDEHYDE DERIVATIVES

被引：15

作者：

ASATO, G

BERKELHAMMER, G

MOON, EL

机构：

[1] Chemical Research and Development Laboratories, Agricultural Division, American Cyanamid Company, Princeton

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of derivatives of 2-thiazolecarboxaldehyde, 2-nitro-5-thiazolecarboxaldehyde, 5-nitro-2-thiazolecarboxaldehyde, and 4-nitro-2-thiazolecarboxaldehyde was synthesized and assayed for antimicrobial activity. Only 2,5-disubstituted thiazoles in which one substituent is a nitro group were active against microorganisms in vitro. 1-{[(5-Nitro-2-thiazolyl)methylene]amino}-2-imidazolidinone exhibited activity against Staphylococcus aureus and Escherichia coli infections in mice. © 1969, American Chemical Society. All rights reserved.

引用

页码：374 / +

页数：1

共 22 条

[11] ANTIMICROBIALS .I. 5-NITROFURAN ANALOGUES [J].

JOHNSTON, RG ;

KIDD, D .

JOURNAL OF THE CHEMICAL SOCIETY, 1964, (DEC) :4730-&

[12]

KAMETANI T, 1963, J PHARM SCO JAP, V83, P174

[13] CHEMOTHERAPEUTIC NITROFURANS .4. SOME DERIVATIVES OF 1-AMINO-2-IMIDAZOLIDIN-ONE, 1-AMINO-2-PYRROLIDINONE AND 3-AMINO-2-THIAZOLIDINONE [J].

MICHELS, JG ;

GEVER, G .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1956, 78 (20) :5349-5351

[14]

MIURA K., 1967, PROGR MED CHEM, VVol. 5-5, P320, DOI 10.1016/S0079-6468(08)70446-6

[15]

Paul H.E., 1964, EXP CHEMOTHER, VII, P307

[16]

PAUL HE, 1964, EXPERIMENTAL CHEMO 1, V2, P316

[17]

SCHINTZER RJ, 1964, EXPERIMENTAL CH 1 ED, V2, P316

[18]

SCHINTZER RJ, 1964, EXPERIMENTAL CH 1 ED, V2, P307

[19]

TANIYAMA H, 1953, J PHARM SOC JAP, V73, P276

[20]

1965, Patent No. 6503442

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