NITROHETEROCYCLIC ANTIMICROBIAL AGENTS .I. NITROTHIAZOLECARBOXALDEHYDE DERIVATIVES

被引：15
作者：
ASATO, G
BERKELHAMMER, G
MOON, EL
机构：
[1] Chemical Research and Development Laboratories, Agricultural Division, American Cyanamid Company, Princeton
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期
关键词：
D O I：
10.1021/jm00303a007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of derivatives of 2-thiazolecarboxaldehyde, 2-nitro-5-thiazolecarboxaldehyde, 5-nitro-2-thiazolecarboxaldehyde, and 4-nitro-2-thiazolecarboxaldehyde was synthesized and assayed for antimicrobial activity. Only 2,5-disubstituted thiazoles in which one substituent is a nitro group were active against microorganisms in vitro. 1-{[(5-Nitro-2-thiazolyl)methylene]amino}-2-imidazolidinone exhibited activity against Staphylococcus aureus and Escherichia coli infections in mice. © 1969, American Chemical Society. All rights reserved.
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页码：374 / +
页数：1
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