INVOLVEMENT OF CLASS-A CALCIUM CHANNELS IN THE KCL INDUCED CA2+ INFLUX IN HIPPOCAMPAL SYNAPTOSOMES

被引：14
作者：
MALVA, JO
AMBROSIO, AF
CARVALHO, AP
DUARTE, CB
CARVALHO, CM
机构：
[1] UNIV COIMBRA, DEPT ZOOL, CTR NEUROSCI, COIMBRA, PORTUGAL
[2] UNIV MINHO, DEPT BIOL, BRAGA, PORTUGAL
来源：
BRAIN RESEARCH | 1995年 / 696卷 / 1-2期
关键词：
OMEGA-CONOTOXIN GVIA; OMEGA-AGATOXIN IVA; OMEGA-CONOTOXIN MVIIC; VOLTAGE-SENSITIVE CALCIUM CHANNELS; INTRACELLULAR CA2+; HIPPOCAMPAL SYNAPTOSOMES;
D O I：
10.1016/0006-8993(95)00816-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Using Ca2+ channel toxins, we determined the types of voltage-sensitive calcium channels activated by two levels of KCI depolarization in hippocampal synaptosomes. The increase in the intracellular Ca2+ concentration ([Ca2+](i)) induced by 30 mM KCI was equally sensitive to either omega-agatoxin IVA (omega-Aga IVA) or to omega-conotoxin MVIIC (omega-CgTx MVIIC), and the inhibition produced by these two peptides was not additive. The present results indicate that omega-Aga IVA and omega-CgTx MVIIC do not distinguish between two different VSCC in hippocampal synaptosomes and that they both inhibit a channel with the alpha(1A) subunit which is present in the rat hippocampus.
引用
收藏
页码：242 / 245
页数：4
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