MODULATION OF CYTOKINE PRODUCTION IN-VIVO BY DIETARY ESSENTIAL FATTY-ACIDS IN PATIENTS WITH COLORECTAL-CANCER

被引:63
作者
PURASIRI, P [1 ]
MURRAY, A [1 ]
RICHARDSON, S [1 ]
HEYS, SD [1 ]
HORROBIN, D [1 ]
EREMIN, O [1 ]
机构
[1] EFAMOL RES INST, KENTVILLE, NS, CANADA
关键词
COLORECTAL CANCER; CYTOKINES; ESSENTIAL FATTY ACIDS;
D O I
10.1042/cs0870711
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
1. The effects of essential fatty acids (gamma-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid), at a dose of 4.8 g/day, given in combination as dietary supplements, on cytokine production were investigated in patients with colorectal cancer. 2. Total serum cytokines - interleukin (interleukin-1 beta, 2, 4 and 6), tumour necrosis factor-alpha and interferon-gamma - were analysed using the enzyme-linked immunosorbent assay technique at different time intervals during the course of essential fatty acid supplementation. 3. Fatty acid uptake and patient compliance were confirmed by a significant increase in serum levels of gamma-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid in all three fractions: triacylglycerol, cholesterol and phospholipid. 4. There was no significant alteration in total serum cytokine concentration/levels in the first 2 months of essential fatty acid ingestion, but the levels of serum cytokines steadily declined thereafter, reaching minimum levels after 6 months of essential fatty acid supplementation. 5. Essential fatty acids, at the dose and duration (6 months) used in this study, reduced total serum interleukin-1 beta levels by 61% (P=0.044), interleukin-2 by 63% (P=0.05), interleukin-4 by 69% (P=0.025), interleukin-6 by 83% (P=0.030), tumour necrosis factor-a by 73% (P=0.040) and interferon-gamma by 67% (P=0.050). 6. Three months after cessation of essential fatty acid intake, however, these cytokine levels returned to presupplementation values. 7. This present study has shown that long-term n - 3 and n - 6 EFA ingestion results in a significant reduction in circulating key cytokines. The precise mechanism of this reduction is unclear.
引用
收藏
页码:711 / 717
页数:7
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