Survival after radical resection for locally advanced gallbladder squamous cell carcinoma: A case report

Introduction: Squamous cell carcinomas primarily arising from the gallbladder are rare. Tumors are usually discovered in an advanced stage and adjuvant modalities are ineffective, leading to a dismal prognosis. Although surgery is potentially curative, very few patients present with resectable disease. Case Report: A 65-year-old female was admitted for an intra-abdominal mass which on preoperative imaging originated from the gallbladder. Laparotomy revealed a huge gallbladder tumor invading the adjacent gastric antrum and the transverse colon. Cholecystectomy with en bloc hepatic segmentectomy, antrectomy, transverse colectomy and lymphadenectomy was performed. Histopathologic examination revealed squamous cell carcinoma originating from the gallbladder. Patient remains disease free 10 years after the operation. Conclusion: Surgery remains as the only potentially curative therapy for locally advanced squamous cell carcinoma.