MOLECULAR-CLONING AND CHROMOSOMAL LOCALIZATION TO 17Q21 OF THE HUMAN WNT3-GENE

被引：23
|
作者：
ROELINK, H
WANG, J
BLACK, DM
SOLOMON, E
NUSSE, R
机构：
[1] STANFORD UNIV,BECKMAN CTR,DEPT DEV BIOL,HOWARD HUGHES MED INST,STANFORD,CA 94305
[2] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND
来源：
GENOMICS | 1993年 / 17卷 / 03期
关键词：
D O I：
10.1006/geno.1993.1412
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In mouse mammary tumors, the Wnt-3 gene can be activated by proviral insertion. Here we report on the isolation of a human homolog, WNT3. A genomic clone was isolated by use of mouse Wnt-3 sequences as a probe, after which cDNA containing most of the protein-encoding domain of the human gene was obtained by PCR. Comparison between the deduced mouse and human WNT-3 protein sequences showed four changes in 333 amino acids. WNT3 is located on chromosome 17q21. The gene was not found to be amplified or rearranged in a collection of human breast tumors. © 1993 Academic Press, Inc.
引用
收藏
页码：790 / 792
页数：3
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