DISORAZOL-A, AN EFFICIENT INHIBITOR OF EUKARYOTIC ORGANISMS ISOLATED FROM MYXOBACTERIA

被引：57

作者：

IRSCHIK, H ^{[1
]}

JANSEN, R ^{[1
]}

GERTH, K ^{[1
]}

HOFLE, G ^{[1
]}

REICHENBACH, H ^{[1
]}

机构：

[1] GESELL BIOTECHNOL FORSCH MBH,DEPT CHEM NAT PROD,W-3300 BRAUNSCHWEIG,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 01期

关键词：

D O I：

10.7164/antibiotics.48.31

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new antibiotic, disorazol, was isolated from the culture broth of the myxobacterium, Sorangium cellulosum strain So ce 12. It is a macrocyclic compound containing two oxazole rings. The antibiotic acted against many fungi and mammalian cell cultures. The latter responded to extremely low doses (MIC 3 similar to 30 pg/ml). None of the tested bacteria and yeasts were inhibited.

引用

页码：31 / 35

页数：5

共 6 条

[1] EFFECT OF BARBITAL ON BIOSYNTHESIS OF STREPTOMYCIN IN STREPTOMYCES-GRISEUS
HEDING, H
GURTU, AK
[J]. JOURNAL OF ANTIBIOTICS, 1977, 30 (10) : 879 - 880
[2] ANTIBIOTICS FROM GLIDING BACTERIA .32. THE SORANGICINS, NOVEL AND POWERFUL INHIBITORS OF EUBACTERIAL RNA-POLYMERASE ISOLATED FROM MYXOBACTERIA
IRSCHIK, H
JANSEN, R
GERTH, K
HOFLE, G
REICHENBACH, H
[J]. JOURNAL OF ANTIBIOTICS, 1987, 40 (01) : 7 - 13
[3] ANTIBIOTICS FROM GLIDING BACTERIA .10. THE MYXOVALARGINS, NEW PEPTIDE ANTIBIOTICS FROM MYXOCOCCUS-FULVUS (MYXOBACTERALES) .1. CULTIVATION, ISOLATION, AND SOME CHEMICAL AND BIOLOGICAL PROPERTIES
IRSCHIK, H
GERTH, K
KEMMER, T
STEINMETZ, H
REICHENBACH, H
[J]. JOURNAL OF ANTIBIOTICS, 1983, 36 (01) : 6 - 12
[4] JANSEN R, 1989, LIEBIGS ANN CHEM, P111
[5] JANSEN R, IN PRESS LIEBIGS ANN
[6] RIFOMYCIN .14. PRODUCTION OF RIFOMYCIN B
MARGALITH, P
PAGANI, H
[J]. APPLIED MICROBIOLOGY, 1961, 9 (04) : 325 - &

← 1 →