CLONIDINE HYPOTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR) DEPENDS ON THE FUNCTIONAL-STATE OF GABAERGIC AND GLUTAMATERGIC SYSTEMS

被引：20
作者：
JASTRZEBSKI, Z
CZYZEWSKASZAFRAN, H
GOZLINSKA, B
REMISZEWSKA, M
MAZUREK, AP
机构：
[1] Department of Pharmacology, Drug Institute, 00-725 Warsaw
来源：
NEUROSCIENCE LETTERS | 1995年 / 184卷 / 02期
关键词：
HYPERTENSION; CLONIDINE; BICUCULLINE; DIZOCILPINE; SPONTANEOUSLY HYPERTENSIVE RATS; WISTAR-KYOTO (WKY) RATS;
D O I：
10.1016/0304-3940(94)11177-K
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of gamma-aminobutyric acid (GABA)(A) receptors and of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor blockade on clonidine hypotension was studied. The experiments were performed on spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY), rats. We found that the blockade of GABA(A) receptors by bicuculline significantly (P < 0.01) reduced hypotensive responses to clonidine. Similarly, the NMDA receptor antagonist dizocilpine (MK-801) completely abolished the blood pressure lowering effect of clonidine. Our findings support the conclusion that clonidine hypotension is closely related to the functional state of both inhibitory GABAergic and excitatory glutamatergic systems.
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页码：94 / 96
页数：3
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