ANALYSIS OF HEPATITIS-C VIRUS ISOLATES AMONG HEALTHY BLOOD-DONORS AND DRUG-ADDICTS IN CHIANG-MAI, THAILAND

被引：57
作者：
APICHARTPIYAKUL, C
CHITTIVUDIKARN, C
MIYAJIMA, H
HOMMA, M
HOTTA, H
机构：
[1] KOBE UNIV,SCH MED,DEPT MICROBIOL,CHUO KU,KOBE 650,JAPAN
[2] CHIANG MAI UNIV,FAC MED,DEPT MICROBIOL,CHIANG MAI 50002,THAILAND
[3] NO DRUG DEPENDENT TREATMENT CTR,CHIANG MAI 50150,THAILAND
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 1994年 / 32卷 / 09期
关键词：
D O I：
10.1128/JCM.32.9.2276-2279.1994
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hepatitis C virus (HCV) isolates obtained from 25 anti-HCV antibody-positive healthy blood donors and 29 drug addicts in Chiang Mai, Thailand, were analyzed. HCV RNA was detected in 23 blood donor samples (92%) and 24 drug addict blood samples (83%) by PCR for a portion of the NS5 region. Subtype analysis revealed that HCV type 3a (HCV-3a) was the prevailing subtype (30%), which was followed in prevalence by HCV-1a (21%), -1b (13%), -3b (13%), and -6a (2%). Six (13%) of the 47 isolates showed low sequence similarities with known types and subtypes. The sequence variants could be grouped into four branches in a molecular evolutionary phylogenetic tree.
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页码：2276 / 2279
页数：4
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