NUCLEOTIDE, DINUCLEOTIDE AND TRINUCLEOTIDE FREQUENCIES EXPLAIN PATTERNS OBSERVED IN CHAOS GAME REPRESENTATIONS OF DNA-SEQUENCES

被引：72
作者：
GOLDMAN, N
机构：
[1] Laboratory of Mathematical Biology, National Institute for Medical Research, London NW7 1AA, The Ridgeway, Mill Hill
来源：
NUCLEIC ACIDS RESEARCH | 1993年 / 21卷 / 10期
关键词：
D O I：
10.1093/nar/21.10.2487
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The chaos game representation (CGR) is a scatter plot derived from a DNA sequence, with each point of the plot corresponding to one base of the sequence. If the DNA sequence were a random collection of bases, the CGR would be a uniformly filled square; conversely, any patterns visible in the CGR represent some pattern (information) in the DNA sequence. In this paper, patterns previously observed in a variety of DNA sequences are explained solely in terms of nucleotide, dinucleotide and trinucleotide frequencies.
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页码：2487 / 2491
页数：5
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