IDENTIFICATION OF A NEW MEMBER OF THE PROTEGRIN FAMILY BY CDNA CLONING

被引：90

作者：

ZHAO, CQ ^{[1
]}

LIU, LD ^{[1
]}

LEHRER, RI ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, CTR HLTH SCI, DEPT MED, LOS ANGELES, CA 90024 USA

来源：

FEBS LETTERS | 1994年 / 346卷 / 2-3期

关键词：

PROTEGRIN; CDNA CLONING; PG-4; CATHELIN; ANTIMICROBIAL PEPTIDE;

D O I：

10.1016/0014-5793(94)00493-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The porcine leukocyte protegrins are a family of cysteine-rich antimicrobial peptides the primary structures of which combine features of defensins and tachyplesins. We cloned three protegrins from porcine bone marrow mRNA by PCR, including one (PG-4) that was previously unknown. The 691 bp protegrin cDNAs were > 98.8% identical, and each was surrounded by highly conserved 5' and (in some instances) 3' sequences present in structurally dissimilar antimicrobial and LPS-binding peptides of animal leukocytes.

引用

页码：285 / 288

页数：4

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