EFFECTS OF DANAZOL ON ENDOMETRIAL DNA-SYNTHESIS IN RATS

被引：3
|
作者：
SUZUKI, S
SAKAMOTO, S
KUDO, H
SASSA, S
SUGIURA, Y
KUWA, K
KASAHARA, N
MORI, T
NAGASAWA, H
机构：
[1] TOKYO MED & DENT UNIV,MED RES INST,DEPT ENDOCRINOL,1-5-45 YUSHIMA,BUNKYO KU,TOKYO 113,JAPAN
[2] UNIV TOKYO,FAC SCI,INST ZOOL,TOKYO 113,JAPAN
[3] MEIJI UNIV,EXPTL ANIM RES LAB,KAWASAKI,KANAGAWA 222,JAPAN
来源：
STEROIDS | 1993年 / 58卷 / 11期
关键词：
DANAZOL; ENDOMETRIUM; DNA SYNTHESIS;
D O I：
10.1016/0039-128X(93)90034-K
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The suppressive effects of Danazol, an isoxazol derivative of the synthetic steroid 17 alpha-ethinyltestosterone, on endometrial DNA synthesis were investigated in rats by immunohistochemistry with bromodeoxyuridine (BrdU) and DNA-synthesizing enzyme assays. Rats treated with Danazol for 14 days at 17-19 weeks of age showed a decrease of plasma gonadotropins associated with ovarian hypofunction, persistent diestrus, and a smaller number of corpora lutea in ovary, resulting in no BrdU-immunoreactive (S-phase) cells in endometrial epithelium and lower activity of thymidine kinase in the uterus compared with control.
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页码：551 / 553
页数：3
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