EFFECTS OF DANAZOL ON ENDOMETRIAL DNA-SYNTHESIS IN RATS

被引：3
|
作者：
SUZUKI, S
SAKAMOTO, S
KUDO, H
SASSA, S
SUGIURA, Y
KUWA, K
KASAHARA, N
MORI, T
NAGASAWA, H
机构：
[1] TOKYO MED & DENT UNIV,MED RES INST,DEPT ENDOCRINOL,1-5-45 YUSHIMA,BUNKYO KU,TOKYO 113,JAPAN
[2] UNIV TOKYO,FAC SCI,INST ZOOL,TOKYO 113,JAPAN
[3] MEIJI UNIV,EXPTL ANIM RES LAB,KAWASAKI,KANAGAWA 222,JAPAN
来源：
STEROIDS | 1993年 / 58卷 / 11期
关键词：
DANAZOL; ENDOMETRIUM; DNA SYNTHESIS;
D O I：
10.1016/0039-128X(93)90034-K
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The suppressive effects of Danazol, an isoxazol derivative of the synthetic steroid 17 alpha-ethinyltestosterone, on endometrial DNA synthesis were investigated in rats by immunohistochemistry with bromodeoxyuridine (BrdU) and DNA-synthesizing enzyme assays. Rats treated with Danazol for 14 days at 17-19 weeks of age showed a decrease of plasma gonadotropins associated with ovarian hypofunction, persistent diestrus, and a smaller number of corpora lutea in ovary, resulting in no BrdU-immunoreactive (S-phase) cells in endometrial epithelium and lower activity of thymidine kinase in the uterus compared with control.
引用
收藏
页码：551 / 553
页数：3
相关论文
共 50 条
  • [11] EFFECTS OF RECOMBINANT-HUMAN-ERYTHROPOIETIN ON DNA-SYNTHESIS IN RAT HEMATOPOIETIC ORGANS
    NAKAYAMA, T
    KUDO, H
    SUZUKI, S
    SUENAGA, M
    SAKAMOTO, S
    ACTA HAEMATOLOGICA, 1994, 91 (04) : 194 - 198
  • [12] EFFECTS OF DIETARY-PROTEIN ON THE INDUCTION OF DNA-SYNTHESIS AND EXPRESSION OF GROWTH-RELATED GENES IN LIVER AND KIDNEY OF GROWING RATS
    YOKOTA, T
    KANAMOTO, R
    HAYASHI, SI
    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 1995, 41 (02) : 227 - 239
  • [13] EFFECTS OF ETOPOSIDE ON STAGE-SPECIFIC DNA-SYNTHESIS DURING RAT SPERMATOGENESIS
    HAKOVIRTA, H
    PARVINEN, M
    LAHDETIE, J
    MUTATION RESEARCH, 1993, 301 (03): : 189 - 193
  • [14] OXIDANT-INDUCED INHIBITION OF DNA-SYNTHESIS
    SESTILI, P
    FIORANI, M
    CATTABENI, F
    CANTONI, O
    ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 1991, 19 (01): : 84 - 86
  • [15] POSTMENOPAUSAL ENDOMETRIAL HYPERPLASIA - ROLE OF DANAZOL THERAPY
    MARIANI, L
    SEDATI, A
    GIOVINAZZI, R
    SINDICO, R
    ATLANTE, G
    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 1994, 44 (02) : 155 - 159
  • [16] ERRORS IN DNA-SYNTHESIS - A SOURCE OF SPONTANEOUS MUTATIONS
    LOEB, LA
    CHENG, KC
    MUTATION RESEARCH, 1990, 238 (03): : 297 - 304
  • [17] Impact of microdrops on solid surfaces for DNA-synthesis
    Maier, C
    Wiesche, SAD
    Hofer, EP
    2000 INTERNATIONAL CONFERENCE ON MODELING AND SIMULATION OF MICROSYSTEMS, TECHNICAL PROCEEDINGS, 2000, : 586 - 589
  • [18] COMPARISON OF DNA-SYNTHESIS IN WHITE AND BROWN ADIPOSE-TISSUE IN RATS WITH VENTROMEDIAL HYPOTHALAMIC-LESIONS
    KIBA, T
    TANAKA, K
    HOSHINO, M
    NUMATA, K
    INOUE, S
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1993, 424 (02): : 122 - 128
  • [19] ASSOCIATION OF POLY(ADP-RIB) SYNTHESIS WITH CESSATION OF DNA-SYNTHESIS AND DNA FRAGMENTATION
    BERGER, NA
    PETZOLD, SJ
    BERGER, SJ
    BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 564 (01) : 90 - 104
  • [20] EFFICIENCY OF DNA-SYNTHESIS INITIATED BY COMPLEMENTARY AND MISMATCHED PRIMERS
    DYACHENKO, LB
    CHENCHIK, AA
    KHASPEKOV, GL
    TATARENKO, AO
    BIBILASHVILI, RS
    MOLECULAR BIOLOGY, 1994, 28 (05) : 654 - 660
12345