EFFECTS OF DANAZOL ON ENDOMETRIAL DNA-SYNTHESIS IN RATS

被引：3
作者：
SUZUKI, S
SAKAMOTO, S
KUDO, H
SASSA, S
SUGIURA, Y
KUWA, K
KASAHARA, N
MORI, T
NAGASAWA, H
机构：
[1] TOKYO MED & DENT UNIV,MED RES INST,DEPT ENDOCRINOL,1-5-45 YUSHIMA,BUNKYO KU,TOKYO 113,JAPAN
[2] UNIV TOKYO,FAC SCI,INST ZOOL,TOKYO 113,JAPAN
[3] MEIJI UNIV,EXPTL ANIM RES LAB,KAWASAKI,KANAGAWA 222,JAPAN
来源：
STEROIDS | 1993年 / 58卷 / 11期
关键词：
DANAZOL; ENDOMETRIUM; DNA SYNTHESIS;
D O I：
10.1016/0039-128X(93)90034-K
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The suppressive effects of Danazol, an isoxazol derivative of the synthetic steroid 17 alpha-ethinyltestosterone, on endometrial DNA synthesis were investigated in rats by immunohistochemistry with bromodeoxyuridine (BrdU) and DNA-synthesizing enzyme assays. Rats treated with Danazol for 14 days at 17-19 weeks of age showed a decrease of plasma gonadotropins associated with ovarian hypofunction, persistent diestrus, and a smaller number of corpora lutea in ovary, resulting in no BrdU-immunoreactive (S-phase) cells in endometrial epithelium and lower activity of thymidine kinase in the uterus compared with control.
引用
收藏
页码：551 / 553
页数：3
相关论文
共 19 条
[11]   DANAZOL EFFECTS ON GONADOTROPIN IN BASAL LEVELS AND PITUITARY RESPONSIVENESS TO LH-RH IN IMMATURE MALE RATS [J].
PEDROZA, E ;
VILCHEZMARTINEZ, JA ;
ARIMURA, A ;
SCHALLY, AV .
CONTRACEPTION, 1978, 17 (01) :61-69
[12]   PITUITARY GONADOTROPIN INHIBITORY ACTIVITY OF DANAZOL [J].
POTTS, GO ;
BEYLER, AL ;
SCHANE, HP .
FERTILITY AND STERILITY, 1974, 25 (04) :367-372
[13]  
Sakamoto S, 1991, Thyroid, V1, P347, DOI 10.1089/thy.1991.1.347
[14]   RELATIVE ACTIVITIES OF THYMIDYLATE SYNTHETASE AND THYMIDINE KINASE IN 1,2-DIMETHYLHYDRAZINE-INDUCED COLON CARCINOMAS IN RATS [J].
SAKAMOTO, S ;
KUWA, K ;
TSUKADA, K ;
SAGARA, T ;
KASAHARA, N ;
OKAMOTO, R .
CARCINOGENESIS, 1987, 8 (03) :405-408
[15]   EFFECTS OF DANAZOL ON DNA-SYNTHESIS IN RAT PROSTATE [J].
SAKAMOTO, S ;
MORI, T ;
SAWAKI, K ;
SASSA, S ;
SUZUKI, S ;
SUGIURA, Y ;
KUDO, H ;
KASAHARA, N ;
NAGASAWA, H .
PROSTATE, 1993, 22 (02) :119-124
[16]  
SAKAMOTO S, 1992, In Vivo (Attiki), V6, P141
[17]  
SHANE JM, 1978, FERTIL STERIL, V29, P637
[18]   SUPPRESSION OF THE DEVELOPMENT OF UTERINE ADENOMYOSIS BY DANAZOL TREATMENT IN MICE [J].
SINGTRIPOP, T ;
MORI, T ;
SAKAMOTO, S ;
SASSA, S ;
PARK, MK ;
KAWASHIMA, S .
LIFE SCIENCES, 1992, 51 (14) :1119-1125
[19]  
TAYLOR AT, 1972, J BIOL CHEM, V247, P1930
12