EFFECTS OF DANAZOL ON ENDOMETRIAL DNA-SYNTHESIS IN RATS

被引：3

作者：

SUZUKI, S

SAKAMOTO, S

KUDO, H

SASSA, S

SUGIURA, Y

KUWA, K

KASAHARA, N

MORI, T

NAGASAWA, H

机构：

[1] TOKYO MED & DENT UNIV,MED RES INST,DEPT ENDOCRINOL,1-5-45 YUSHIMA,BUNKYO KU,TOKYO 113,JAPAN

[2] UNIV TOKYO,FAC SCI,INST ZOOL,TOKYO 113,JAPAN

[3] MEIJI UNIV,EXPTL ANIM RES LAB,KAWASAKI,KANAGAWA 222,JAPAN

来源：

STEROIDS | 1993年 / 58卷 / 11期

关键词：

DANAZOL; ENDOMETRIUM; DNA SYNTHESIS;

D O I：

10.1016/0039-128X(93)90034-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The suppressive effects of Danazol, an isoxazol derivative of the synthetic steroid 17 alpha-ethinyltestosterone, on endometrial DNA synthesis were investigated in rats by immunohistochemistry with bromodeoxyuridine (BrdU) and DNA-synthesizing enzyme assays. Rats treated with Danazol for 14 days at 17-19 weeks of age showed a decrease of plasma gonadotropins associated with ovarian hypofunction, persistent diestrus, and a smaller number of corpora lutea in ovary, resulting in no BrdU-immunoreactive (S-phase) cells in endometrial epithelium and lower activity of thymidine kinase in the uterus compared with control.

引用

页码：551 / 553

页数：3

共 19 条

[1] DANAZOL INHIBITS STEROIDOGENESIS IN RAT TESTIS INVITRO [J].