HOMOLOGY MODEL-BUILDING OF THE THYROID TRANSCRIPTION FACTOR-I HOMEODOMAIN

被引：13

作者：

FOGOLARI, F ^{[1
]}

ESPOSITO, G ^{[1
]}

VIGLINO, P ^{[1
]}

DAMANTE, G ^{[1
]}

PASTORE, A ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB,STRUCT & BIOCOMP PROGRAM,W-6900 HEIDELBERG,GERMANY

来源：

PROTEIN ENGINEERING | 1993年 / 6卷 / 05期

关键词：

HOMEODOMAIN; TRANSCRIPTION FACTOR; HOMOLOGY MODELING; 3-D STRUCTURE;

D O I：

10.1093/protein/6.5.513

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A possible structure for the homeodomain of rat thyroid transcription factor 1 is proposed on the basis of the homology with other homeodomains whose structures have been solved by X-ray crystallography. A structure very similar to the reference ones is feasible and may account for the observed DNA-binding specificity. Structural features of the model, which are likely to be shared by other homeodomains, are discussed and may help researchers in the field to analyse their own experimental data.

引用

页码：513 / 519

页数：7

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