INSULIN-DEPENDENT DIABETES-MELLITUS

被引：13
|
作者：
BACH, JF
机构：
[1] Hôpital Neckar, Paris
来源：
CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 06期
关键词：
D O I：
10.1016/S0952-7915(05)80011-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type I diabetes occurs as a result of T-cell-mediated beta-cell destruction. Several candidate antigens have been described recently, including glutamic acid decarboxylase, heat shock protein 65 and perpherin. Restricted T-cell receptor V-beta gene usage in non-obese diabetic mice has been suggested but not yet proven. In addition to major histocompatibility genes, several non-H-2 predisposing genes have been mapped on chromosomes 1, 3 and 11.
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页码：902 / 905
页数：4
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