ACTIVATION OF LYT-2 ASSOCIATED WITH DISTANT UPSTREAM INSERTION OF AN SL3-3 PROVIRUS

被引：2

作者：

ANSON, DS ^{[1
]}

CLARKIN, K ^{[1
]}

HYMAN, R ^{[1
]}

机构：

[1] SALK INST, DEPT CANC BIOL, POB 85800, SAN DIEGO, CA 92186 USA

来源：

IMMUNOGENETICS | 1992年 / 36卷 / 01期

关键词：

D O I：

10.1007/BF00209286

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Two Lyt-2+ mutants of the T-cell lymphoma SL12.4.10 were selected by fluorescence activated cell sorting. Both mutants expressed Lyt-2 (CD8 alpha-chain) but not Lyt-3 (CD8 beta-chain). Derivatives of one Lyt-2+ mutant that expressed Lyt-3 could be isolated by sorting for Lyt-3+ cells. Southern blotting analysis indicated that both mutants had structural rearrangements within or immediately 3' of the Lyt-3 gene, accompanied by demethylation of at least one Hpa II site within the Lyt-2 gene. Gene cloning analysis of one mutant demonstrated that the structural rearrangement was due to insertion of an SL3-3 provirus 35 kb 5' to the Lyt-2 gene. It is likely that Lyt-2 gene activation is a direct or indirect consequence of proviral insertion at this site.

引用

页码：3 / 14

页数：12

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