D-SERINE ANTAGONIZED PHENCYCLIDINE-INDUCED AND MK-801-INDUCED STEREOTYPED BEHAVIOR AND ATAXIA

被引：107
|
作者：
CONTRERAS, PC
机构：
[1] CNS Diseases Research, G.D. Searle and Company, St. Louis
来源：
NEUROPHARMACOLOGY | 1990年 / 29卷 / 03期
关键词：
ataxia; D-Serine; glycine; PCP; stereotypy;
D O I：
10.1016/0028-3908(90)90015-J
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
D-Serine, a selective agonist at the strychnine-insensitive glycine binding site, antagonized PCP-induction of stereotyped behavior and ataxia in a dose-dependent manner. At intraventricular doses of 0.1, 0.5 and 1 μmol/rat, Dserine significantly attenuated PCP-induction of stereotyped behavior in rats. Only doses of 0.5 and 1.0 μmol/rat of D-serine antagonized PCP-induction of ataxia. D-Serine (0.5 μmol/rat) also antagonized MK-801 induced stereotyped behavior and ataxia. These results suggest that agonists at the strychnineinsensitive glycine site may be clinically useful as a novel class of atypical antipsychotic agents. © 1990.
引用
收藏
页码：291 / 293
页数：3
相关论文
共 50 条
  • [21] Exogenously administered D-serine failed to potentiate the ability of MK-801 to antagonize electrically precipitated seizures in nonhandled control and stressed mice
    Long, Katrice D.
    Mastropaolo, John
    Rosse, Richard B.
    Deutsch, Stephen I.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2007, 17 (01) : 53 - 57
  • [22] Age-related differential sensitivity to MK-801-induced locomotion and stereotypy in C57BL/6 mice
    Qi, Chunting
    Zou, Hong
    Zhang, Ruizhong
    Zhao, Guoping
    Jin, Meilei
    Yu, Lei
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 580 (1-2) : 161 - 168
  • [23] Effects of aripiprazole on MK-801-induced prepulse inhibition deficits and mitogen-activated protein kinase signal transduction pathway
    Ishii, Daisuke
    Matsuzawa, Daisuke
    Kanahara, Nobuhisa
    Matsuda, Shingo
    Sutoh, Chihiro
    Ohtsuka, Hiroyuki
    Nakazawa, Ken
    Kohno, Mami
    Hashimoto, Kenji
    Iyo, Masaomi
    Shimizu, Eiji
    NEUROSCIENCE LETTERS, 2010, 471 (01) : 53 - 57
  • [24] The bombesin/gastrin releasing peptide receptor antagonist RC-3095 blocks apomorphine but not MK-801-induced stereotypy in mice
    Meller, CA
    Henriques, JAP
    Schwartsmann, G
    Roesler, R
    PEPTIDES, 2004, 25 (04) : 585 - 588
  • [25] STEREOSELECTIVE INHIBITION BY D-ALANINE AND L-ALANINE OF PHENCYCLIDINE-INDUCED LOCOMOTOR STIMULATION IN THE RAT
    TANII, Y
    NISHIKAWA, T
    HASHIMOTO, A
    TAKAHASHI, K
    BRAIN RESEARCH, 1991, 563 (1-2) : 281 - 284
  • [26] Substance P potentiates thermal hyperalgesia induced by intrathecal administration of D-serine in rats
    Zhang, YH
    Shu, YS
    Zhao, ZQ
    ACTA PHARMACOLOGICA SINICA, 2001, 22 (09) : 817 - 820
  • [27] Prenatal exposure to an NMDA receptor antagonist, MK-801 reduces density of parvalbumin-immunoreactive GABAergic neurons in the medial prefrontal cortex and enhances phencyclidine-induced hyperlocomotion but not behavioral sensitization to methamphetamine in postpubertal rats
    Abekawa, Tomohiro
    Ito, Koki
    Nakagawa, Shin
    Koyama, Tsukasa
    PSYCHOPHARMACOLOGY, 2007, 192 (03) : 303 - 316
  • [28] Spatial memory deficits induced by perinatal treatment of rats with PCP and reversal effect of D-serine
    Andersen, JD
    Pouzet, B
    NEUROPSYCHOPHARMACOLOGY, 2004, 29 (06) : 1080 - 1090
  • [29] Prenatal exposure to an NMDA receptor antagonist, MK-801 reduces density of parvalbumin-immunoreactive GABAergic neurons in the medial prefrontal cortex and enhances phencyclidine-induced hyperlocomotion but not behavioral sensitization to methamphetamine in postpubertal rats
    Tomohiro Abekawa
    Koki Ito
    Shin Nakagawa
    Tsukasa Koyama
    Psychopharmacology, 2007, 192 : 303 - 316
  • [30] Reversal of Phencyclidine-Induced Dopaminergic Dysregulation by N-Methyl-D-Aspartate Receptor/Glycine-site Agonists
    Daniel C Javitt
    Andrea Balla
    Sarah Burch
    Ray Suckow
    Shan Xie
    Henry Sershen
    Neuropsychopharmacology, 2004, 29 : 300 - 307
12345