D-SERINE ANTAGONIZED PHENCYCLIDINE-INDUCED AND MK-801-INDUCED STEREOTYPED BEHAVIOR AND ATAXIA

被引：107
作者：
CONTRERAS, PC
机构：
[1] CNS Diseases Research, G.D. Searle and Company, St. Louis
来源：
NEUROPHARMACOLOGY | 1990年 / 29卷 / 03期
关键词：
ataxia; D-Serine; glycine; PCP; stereotypy;
D O I：
10.1016/0028-3908(90)90015-J
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
D-Serine, a selective agonist at the strychnine-insensitive glycine binding site, antagonized PCP-induction of stereotyped behavior and ataxia in a dose-dependent manner. At intraventricular doses of 0.1, 0.5 and 1 μmol/rat, Dserine significantly attenuated PCP-induction of stereotyped behavior in rats. Only doses of 0.5 and 1.0 μmol/rat of D-serine antagonized PCP-induction of ataxia. D-Serine (0.5 μmol/rat) also antagonized MK-801 induced stereotyped behavior and ataxia. These results suggest that agonists at the strychnineinsensitive glycine site may be clinically useful as a novel class of atypical antipsychotic agents. © 1990.
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页码：291 / 293
页数：3
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