EFFECTS OF TABLET CORE DIMENSIONAL INSTABILITY ON THE GENERATION OF INTERNAL-STRESSES WITHIN FILM COATS .2. TEMPERATURE AND RELATIVE-HUMIDITY VARIATION WITHIN A TABLET BED DURING AQUEOUS FILM COATING IN AN ACCELA-COTA

被引：10

作者：

OKUTGEN, E ^{[1
]}

JORDAN, M ^{[1
]}

HOGAN, JE ^{[1
]}

AULTON, ME ^{[1
]}

机构：

[1] COLORCON LTD,ORPINGTON BR5 3QY,KENT,ENGLAND

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1991年 / 17卷 / 09期

关键词：

D O I：

10.3109/03639049109043853

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Temperature and relative humidity variations within a tablet bed were measured during a complete typical aqueous film coating procedure in an Accela-Cota Model 10. Characteristic thermal and moisture patterns on which it was possible to distinguish the stages of coating process were obtained. Inlet air temperature as a processing variable and different locations within the tablet bed were found to influence these patterns significantly.

引用

页码：1191 / 1199

页数：9

共 2 条

[1] EFFECTS OF TABLET CORE DIMENSIONAL INSTABILITY ON THE GENERATION OF INTERNAL-STRESSES WITHIN FILM COATS .1. INFLUENCE OF TEMPERATURE-CHANGES DURING THE FILM COATING PROCESS
OKUTGEN, E
HOGAN, JE
AULTON, ME
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1991, 17 (09) : 1177 - 1189
[2] EFFECTS OF TABLET CORE DIMENSIONAL INSTABILITY ON THE GENERATION OF INTERNAL-STRESSES WITHIN FILM COATS .3. EXPOSURE TO TEMPERATURES AND RELATIVE HUMIDITIES WHICH MIMIC THE FILM COATING PROCESS
OKUTGEN, E
HOGAN, JE
AULTON, ME
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1991, 17 (14) : 2005 - 2016

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