STRIATAL CHOLINERGIC ACTIVITY DURING MORPHINE-INDUCED CATALEPSY IN THE RAT - DEVELOPMENT OF TOLERANCE

被引：6
|
作者：
ROSE, R [1 ]
KUMAR, A [1 ]
BHATTACHARYA, SK [1 ]
机构：
[1] BANARAS HINDU UNIV, INST MED SCI, DEPT PHARMACOL, NEUROPHARMACOL LAB, VARANASI 221005, UTTAR PRADESH, INDIA
来源：
NEUROSCIENCE LETTERS | 1979年 / 14卷 / 01期
关键词：
D O I：
10.1016/0304-3940(79)95355-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Morphine hydrochloride (10 mg/kg, i.p.) induced marked catalepsy in rats, which was associated with significantly enhanced striatal acetylcholine levels and reduced cholinesterase activity. Rapid tolerance to morphine-induced catalepsy was noted after twice daily administrations, the tolerance being discernible after the third injection and was complete after the eleventh injection. With the development of tolerance, morphine-induced effects on striatal acetylcholine and cholinesterase were progressively reversed, confirming striatal cholinergic involvement in morphine-induced catalepsy in the rat. © 1979.
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页码：115 / 118
页数：4
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