SELECTIVE ACTIVATION OF HUMAN BETA-GLOBIN BUT NOT GAMMA-GLOBIN GENE IN HUMAN FIBROBLASTXMOUSE ERYTHROLEUKEMIA CELL HYBRIDS

被引：88
作者：
WILLING, MC
NIENHUIS, AW
ANDERSON, WF
机构：
[1] Laboratory of Molecular Hematology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda
来源：
NATURE | 1979年 / 277卷 / 5697期
关键词：
D O I：
10.1038/277534a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The human α- and β-globin genes have been activated in MEL times; human fibroblast cell hybrids. However, even though the human γ- and β-globin genes are closely linked and were shown in these hybrid clones to be present in approximately equal numbers, no human γ-globin mRNA was produced. Thus, the human β- and γ-globin genes in these cells are differentially regulated apparently by a positive regulatory factor(s) specific for individual globin genes. © 1979 Nature Publishing Group.
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页码：534 / 538
页数：5
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