Modulation of serum BDNF levels in postherpetic neuralgia following pulsed radiofrequency of intercostal nerve and pregabalin

Aim: To study the modulation of serum BDNF levels following integrated multimodal intervention in postherpetic neuralgia (PHN). Materials & methods: A randomized, double-blind controlled study was undertaken among patients of thoracic PHN where 30 patients received pregabalin with pulsed radiofrequency and 30 controls received pregabalin with sham treatment. Results: Pain intensity (visual analog scale) was reduced earlier in intervention group (15.3 +/- 5.7 at the fourth week) compared with control group (16.3 +/- 6.6 at the eighth week). Serum BDNF level increased with time in both the groups with overall increase more pronounced in intervention group. Conclusion: Integrated multimodal therapy using minimally invasive pulsed radiofrequency and pregabalin in PHN was effective in early pain reduction with elevated serum BDNF levels.