COMPARISON OF THE BRONCHODILATOR AND VASODILATOR ACTIVITY OF SODIUM-AZIDE AND SODIUM-NITROPRUSSIDE IN THE GUINEA-PIG

被引：21
作者：
JAMIESON, DD
TAYLOR, KM
机构：
[1] Roche Research Institute of Marine Pharmacology, Dee Why, New South Wales
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1979年 / 6卷 / 05期
关键词：
azide; bronchodilatation; nitroprusside; vasodilatation;
D O I：
10.1111/j.1440-1681.1979.tb00034.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Sodium azide and sodium nitroprusside are potent dilators of the intact guinea‐pig tracheal preparation in vitro. 2. Both substances are bronchodilators in the anaesthetized guinea‐pig in vivo when administered intravenously or by aerosol inhalation. 3. Sodium azide and sodium nitroprusside are also potent vasodilators in the guinea‐pig. 4. At all doses and by any route of administration, including aerosol inhalation, the hypotensive effect predominates over bronchodilatation. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：515 / 525
页数：11
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