EFFECTS OF DRUGS ON THE PROCESSES REGULATING THE FUNCTIONAL-ACTIVITY OF BRAIN MONO-AMINES

被引：0

作者：

GRAHAMESMITH, DG ^{[1
]}

机构：

[1] UNIV OXFORD,RADCLIFFE INFIRM,DEPT CLIN PHARMACOL,OXFORD OX2 6HE,ENGLAND

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY | 1979年 / 3卷 / 1-3期

关键词：

brain monoamine function; drug effects;

D O I：

10.1016/0364-7722(79)90065-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. 1. By study of the synthesis and turnover of brain monoamines and with the use of behavioral models which indicate the functional activity of brain 5HT and dopamine, it is possible to unravel the mechanisms by which some drugs produce behavioral effects. 2. 2. Using these techniques the acute and chronic effects of certain neuroleptics, propramolol and other beta-adrenergic blocking agents, repeated electroconvulsive shock, and lithium upon the functional activity of braint 5HT and dopamine are examined. 3. 3. The clinical relevance of these studies is discussed. © 1979.

引用

页码：15 / 23

页数：9

共 22 条

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BOULLIN, DJ ;

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GRIMES, RPJ ;

GRAHAMESMITH, DG ;

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GELDER, MG ;

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BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1975, 2 (01) :29-35

[2] INHIBITION OF 5-HYDROXYTRYPTAMINE-INDUCED HUMAN-BLOOD PLATELET-AGGREGATION BY CHLORPROMAZINE AND ITS METABOLITES [J].

BOULLIN, DJ ;

GRAHAMESMITH, DG ;

GRIMES, RPJ ;

WOODS, HF .

BRITISH JOURNAL OF PHARMACOLOGY, 1975, 53 (01) :121-125

[3] ELECTROCONVULSIVE SHOCK INCREASES BEHAVIORAL-RESPONSES OF RATS TO BRAIN 5-HYDROXYTRYPTAMINE ACCUMULATION AND CENTRAL NERVOUS-SYSTEM STIMULANT-DRUGS [J].

EVANS, JPM ;

GRAHAMESMITH, DG ;

GREEN, AR ;

TORDOFF, AFC .

BRITISH JOURNAL OF PHARMACOLOGY, 1976, 56 (02) :193-199

[4] INHIBITORY EFFECT OF CHLORPROMAZINE ON SYNDROME OF HYPERACTIVITY PRODUCED BY L-TRYPTOPHAN OR 5-METHOXY-N,N-DIMETHYLTRYPTAMINE IN RATS TREATED WITH A MONOAMINE OXIDASE INHIBITOR [J].

GRAHAMESMITH, DG .

BRITISH JOURNAL OF PHARMACOLOGY, 1971, 43 (04) :856-+

[5]

GRAHAMESMITH DG, 1976, PSYCHOL MED, V6, P523

[6] ROLE OF BRAIN 5-HYDROXYTRYPTAMINE IN HYPERACTIVITY PRODUCED IN RATS BY LITHIUM AND MONOAMINE-OXIDASE INHIBITION [J].

GRAHAMESMITH, DG ;

GREEN, AR .

BRITISH JOURNAL OF PHARMACOLOGY, 1974, 52 (01) :19-26

[7] CONTRASTING ACTIONS OF TRH AND CYCLOHEXIMIDE IN ALTERING EFFECTS OF CENTRALLY ACTING DRUGS - EVIDENCE FOR NON-INVOLVEMENT OF DOPAMINE SENSITIVE ADENYLATE-CYCLASE [J].

GREEN, AR ;

HEAL, DJ ;

GRAHAMESMITH, DG ;

KELLY, PH .

NEUROPHARMACOLOGY, 1976, 15 (10) :591-599

[8] EFFECT OF DIPHENYLHYDANTOIN ON BRAIN 5-HYDROXYTRYPTAMINE METABOLISM AND FUNCTION [J].

GREEN, AR ;

GRAHAMESMITH, DG .

NEUROPHARMACOLOGY, 1975, 14 (02) :107-113

[9] ELEVATION OF BRAIN GABA CONCENTRATIONS WITH AMINO-OXYACETIC ACID - EFFECT ON HYPERACTIVITY SYNDROME PRODUCED BY INCREASED 5-HYDROXYTRYPTAMINE SYNTHESIS IN RATS [J].

GREEN, AR ;

TORDOFF, AFC ;

BLOOMFIELD, MR .

JOURNAL OF NEURAL TRANSMISSION, 1976, 39 (1-2) :103-112

[10] (-)-PROPRANOLOL INHIBITS BEHAVIORAL-RESPONSES OF RATS TO INCREASED 5-HYDROXYTRYPTAMINE IN CENTRAL NERVOUS-SYSTEM [J].

GREEN, AR ;

GRAHAMESMITH, DG .

NATURE, 1976, 262 (5569) :594-596

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