POTASSIUM FLUORIDE ON ALUMINA - CONDENSATION OF 3-METHYL-2-THIONO-4-THIAZOLIDINONE WITH ALDEHYDES - SYNTHESIS OF ALPHA-THIOACRYLIC ACIDS AND PHOSPHONOTHIONOTHIAZOLIDINONES

被引：30
作者：
VILLEMIN, D
BENALLOUM, A
机构：
[1] Ecole Nationale Supérieure d'Ingenieurs de Caen, F-14050 Caen Cedex, I. S.M.R.A.
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1993年 / 79卷 / 1-4期
关键词：
THIAZOLIDINONE; MICHAEL ADDITION; THIOACRYLIC ACIDS; CONDENSATION; ANTIVIRAL; MICROWAVE;
D O I：
10.1080/10426509308034395
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
3-Methyl-2-thiono-4-thiazolidinone and aromatic aldehydes adsorbed on potassium fluoride on alumina gave under microwave irradiation 5-arylidene-3-methyl-2-thiono-4-thiazolidinones in 70% to 90% yield. These compounds can be cleaved with sodium hydroxide on alumina into alpha-thiolacrylic acids in quasi-quantitative yields. Michael addition of diethyl phosphite to 5-arylidene-3-methyl-2-thiono-4-thiazolidinone is described for the first time.
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页码：33 / 41
页数：9
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